Recently bought a Crumpler (37 daily) to use on holiday (it doubled as a handbag) and at the moment it holds my Canon 400 body with the battery grip and 24-70 attached, and has my new 10-20mm and the nifty 50mm in separate compartments. It also holds my spare specs in their case, a polarising filter, a release cable, a lens cloth, spare battery, spare flash card and MP3 player.
In the front section, note pad, pen, tissues, lippy, panadol and mints! Oh, and a Swiss army knife too.
The rest of my gear is half in the AW trekker, half on the sofa in my study. The 70-200mm lives in its own posh case. In theory.....I know where it all is!!