Hmmm, might be changing my mind having read how slow Plusteks are. Should be faster doing B&W but maybe I'd be better spending time refining my DSLR scanning routine as I'm sure that it should be possible to batch crop in lightroom right?
With most of the Plusteks (or Epsons) you have to load the film holder first (you'll get better at this!). With most of the Plusteks you have to manually move the film holder for each new frame, and then fine tune the crop. A preview takes a few seconds (mine is at 900 samples per inch), then I do a two scan multi-scan at 3600 spi. I used to scan at 2400 spi but since that's not a native resolution, you're relying on Vuescan to do the interpolation.
@StephenM recommends a RAW scan, which allows you to revisit the scan at any time and adjust the chosen settings. I only do this very occasionally (mostly slide film so far), as I've found negative inversion from RAW tricky (I don't use LR, so no NLP). Besides, I'm averse to taking up huge amounts of disk space for mostly so-so images, so it's nearly always JPEGs for me.
I probably spend around 1-2 hours per roll of 135 film, usually done off and on during the evening while listening to the radio or checking social media! Makes no difference whether it's colour or black and white (apart from fiddling around in the Color Tab to try and get improved negative conversion), or whether it's JPEG or RAW. 3600 spi scans do take longer than 1800 spi scans.
The Plustek 135i has an interesting feature that a film strip in its holder once fed in will automatically advance. I've never seen or used one, so I don't know how well this works, but it should save you some time, potentially with the loss of small areas round the edge (?). In theory it works with Vuescan, but I was worried about this paragraph: "This scanner is supported on Mac OS X 10.6 (Snow Leopard) and later if you first install the Plustek drivers for Mac OS X 10.6 or later (these will work on newer versions of Mac OS X). Also, run the x32 (not x64) version of VueScan with these drivers." I don't think x32 Vuescan will work in modern MacOS, but that might not be a problem for you!