Yes.
The problem you'd have with multiple slaves is line of sight. I tend to line up mine fairly carefully - but maybe I'm paranoid.
I can't remember haw many flashes are allowed in a group (but I'm sure it's multiples) and the 550ex will work with 3 groups (3 ratios / power outputs).
So off the top of my head you can set the output of groups A, B and C (the Master is in group A). I think you set the ratio of A B and C) then set an EC on C to vary it from B.
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