Yeah... check the mobo manual as to ordering. My latest mobo has 4 slots, A, B, C, D. A&C and B&D are paired, so my two sticks go in alternate slots. What is vitally important is to get the pairing right. I always buy RAM in pairs as for most CPUs there are 2 separate memory channels that can be used so you get more speed out of the memory system if you match the sizes. If you want to mix and match, make sure you get the same voltage and CAS timings. I tend to buy the same memory if I'm adding extra, but I have used non-matched sets in the past (I've had a setup of 2x4G and 2x1G running fine)