I scan monochrome images in colour with my Epson V700, then use the extract the sharpest RGB channel in Photoshop (usually the green one but not always) to create a final greyscale image.
I got into this habit as I have a sneaky suspicion* that a greyscale scan uses all three channels, which leads to a compromise in image quality - there's sometimes a small registration difference between them in the colour scan (might be CA due to the scanning bed glass and/or due to the fixed focus on the V700).
None of the above may apply if you're using a dedicated film scanner or even something other than a V700.
* ISTR running some comparative tests when I first got the scanner that convinced me that this was the way to go.