Well from what I've been shooting up to now I'd say most are under ISO2000 I guess there is a bit more latitude for NR with the higher resolution if needed. I've never been one to use NR other than a tiny tweak in lightroom but I think some of the noise issues woudl be mitigated by me getting hold of Topaz or something.
I recently bought ON1 RAW as well as the upgrade to Capture One V.22 with V.23 coming in November. ON1 RAW is excellent at removing noise, tried a demo on Topaz and it too is impressive, but I didn't like the interface.










