Hi, I have this lens, as well as sigma's 50mm macro. Use the smallest aperture you can with a workable shutter speed - not always easy when handheld. f9 for instance, shooting a grasshopper head on, will give you his head in focus but the DOF will extend only aout half way along his body. Sometimes this is good, I shot a fly at f6.3 where the DOF only covers the eyes, mouthparts and front legs, but it is a good effect. You'll find manual focus is the only possibility for real macro and at 1:1 ratio, i.e. extreme close up, focus is obtained by slight body movement back and forth (when handheld) - you can take loads and 1 out of 10 might be focused where you want! For most smaller aperture shots under natural light a tripod becomes a must. Good luck, look forward to seeing some shots!