If you're taking available light night or low light photographs without flash with subject movement involved then the only answer is a fast lens and probably a high ISO. If it's a static scene with no movement then lens speed and aperture isn't really inportant... you can expose for as long as you like. It's what you decide to meter on which is important
Night and low light photography needs some thought to how you're metering. To use the example of people on stage which someone mentioned earler, then if the surroundings are substantially darker than the smaller lit figures on stage, then using evaluative or averaging metering modes is quite likely to result in the system deciding that the predominantly darker parts of the image are more important if they fill more of the viewfinder, resulting in over-exposure. Spot metering is obviously an advantage, you can meter on a skin tone and use the exposure lock button before you re-compose the shot.
But why not just get as close a skin tone reading as you can from someone on stage? Then switch to manual mode and make the settings for that reading. The viewfinder meter display will be probaby be wildly unbalanced, but that doesn't matter, you're metering for the tones you think are important, not relying on the meter which is reading for the whole scene. If the lighting on stage doesn't change you should be OK to take all your shots with that setting. Obviously shoot RAW to give yourself the best processing latitude.