Not all great imagery has to be documenting tragedy, war, conflict etc. Obviously, it is hard hitting stuff, but what makes a great deal of such imagery poignant and lasting is the subject itself, not necessarily the photograph. I don't think anyone would say Ansel Adams was p***ing about

Just landscape. It has cause and reason though. His work was instrumental in the foundation of protecting what are now national parks. However, they are just landscapes. Cindy Sherman was just essentially taking selfies

... but she was making a good point, at the right time, hence the importance of the work.
I've said it before, and I'll say it again. It's about a passion for the subject... NOT photography: That's what makes images interesting. You see it again, and again over the decades. The images that we now regard as great works are nearly always so because of the subject, and the passion the photographer has for that subject. Passion shines through, and those in a position to judge, publish and buy the work are looking for that too. THAT'S why Ansel Adams' landscapes are in MOMA and Joe Cornish's aren't. You can see the passion and dedication to the subject in Adams' landscapes. You can't in Cornish's. Cornish is just interested in making shiny things to sell books and further his career. I'm sure Adams had a weather eye on that too of course, but it's damned obvious that wasn't what drove him out into the Sierras and Yellowstone time after time after time.
Shoot what you are passionate about. It may not be appropriate for a market when you shoot it, but it's time will come when fashion and trends rotate around like they do, and then you'll have a body of work that everyone will pour over if you're lucky. Good work is shot because the author was driven to shoot it because they love the subject, not their cameras.