As long as its the Canon fit one yes it will work fine. You might want the battery grip as its quite big and the 400d is quite small but that's just preference.
Meant to add that for the price of a 150-500 new you will get a mint 100-400L or 400L or 300L plus TC all of which offer advantages but less FL. Alternatively (and you do not see many around ) you should be able to get a used Siggy 50-500 OS which gives you the FL and which is an altogether better lens.
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