I personally use the sharpening tool in ACR in preference to any other.
Start with the radius set to 1 then hold down the alt key so the image changes to b&w then move the slider to the right until your happy with the results, then place the cursor over the "detail" slider and hit the alt key, you dont want too much detail so I usually move the slider to the left a little.
Finally place the cursor over the masking slider and again hold down the alt key and adjust to taste (helps throw backgrounds out).
If you need to do any noise reduction heres the place to do it as well, use the luminance slider to adjust the level of luminance noise reduction and the detail slider to adjust the level of detail, follow suit with the colour noise reduction as well if needed.
I try to make small adjustments in the sharpening section as over sharpened images can look worse than slightly soft ones in my opinion.
Don't forget contrast adjustment as well, it can affect apparent sharpness and as I often shoot through glass for bird shots it always needs a boost to counter the effect of shooting through glass.
Ps, you can use ACR on jpg's too if you view them in adobe bridge or lightroom then right click and choose open with ACR, works a treat for small adjustments and in my mind is better than using the tools in CS