Depends Lee, if I'm setting up a portrait then yes I will use a meter so I can get the lighting spot on.
If I'm working too fast to get the meter out I will move the flash back and forward depending on the histogram. Flash power works on the inverse sqare law relationship and that means that moving the flash a couple of feet can have quite an effect on the light hitting the subject. Sometimes that's quicker than having to get the flash back down off a stand and turn it up/down. It's cheating but it works.
Don't forget that the way a flash registers on a pic has a LOT to do with the combination of aperture and shutter speed and often a few adjustments there are as important as what the flash is doing.
It's not a very easy subject and I really need to get hold of Zack Arias' One light vid myself!