All personal preference really (along with how much cash you have to drop on a system).
I had the Skyports as I said which are perfectly good triggers, but also used various other third party triggers along the way, and they are all just too much of a hassle for me to be bothered with. Connections get loose, either the cables on the flashes, or the hotshoe controller on camera. They're all fiddly to control from the camera (if they even offer that control). You have to spend time setting stuff up, and getting various bits n pieces out of your bag before you take a shot. You need more and various types of batteries.
A set of 600RTs takes a couple of seconds to set up. I don't have to take my flash off my camera, and I can turn everything up, down, on, off, from camera. Haven't missed a single shot with a misfire since I switched to them. Having the flash on camera is a huge bonus for me shooting events - it means I don't have to do anything to switch from off-camera flash to on-camera (OK I have to press one button). But not having to take triggers on and off, etc saves a massive ballache.
I know some systems let you stick a flash on top of the controller, like the PocketWizards, but they really are some cumbersome buggers aren't they.
Depends how you work though, and what type of work you do. If triggers annoy the hell out of you, like they do me, then switch. If you don't mind them, save your cash.